生物分解性ポリマーソームのオスモス式誘導形状変容による明確に定義された機能的なナノチューブの形成

Loai K E A Abdelmohsen¹, David S Williams¹, Jan Pille¹

¹Institute for Molecules and Materials, Radboud University , Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands.

Journal of the American Chemical Society

|July 5, 2016

まとめ

研究者はポリマーソームから生物分解性ナノチューブを作りましたバイオコンパティブルで高アスペクト比のナノ粒子は薬で満たされ生物医学的な用途のためにタンパク質で機能化できます

科学分野:

バイオマテリアル科学
ナノテクノロジー
ポリマー化学

背景:

ポリマーソームは適応性のあるナノ構造で調節可能な特性があり生物医学的な応用には不可欠です
非球形ポリマーソームは形状に依存する機能性があるため興味がありますが,分解不可能な材料に限定されています.
ナノ医療における形状効果を調査するには,分解可能な非球形のナノ構造が必要です.

研究の目的:

生物分解可能な非球形のポリマーソームを作る方法を開発する.
バイオメディカルアプリケーションにおけるこれらの新しいナノ構造の有用性を実証する.
高面比ナノ粒子のための新しいプラットフォームを確立する.

主な方法:

ポリエチレングリコール-b-ポリエチレングリコール-d,l-ラクチドから作られた球形のポリマーソームをナノチューブに自発的に伸ばす.
ナノチューブのサイズを調節するために透析を用いたオスモティック制御.
バイオ・オートゴーナル・クリック・ケミストリーによるタンパク質によるナノチューブ表面の機能化.

主要な成果:

生物分解性ポリマソームから精密なナノチューブを成功裏に生成した.
オスモティック方法によるナノチューブのサイズ制御が実証された.
ナノチューブの表面に薬物と機能的なタンパク質を装着する能力を確認した

結論:

バイオコンパティブルで高アスペクト比のナノ粒子を作るための新しいプラットフォームを確立しました
生物分解性ポリマーソームは調節可能なサイズのナノチューブに変換できます
これらのナノチューブは薬の投与とナノ医療におけるタンパク質の機能化に有望なシステムを提供します

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