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遺伝的リスクスコアとボディマス指数の関連性
Stefan Walter1, Iván Mejía-Guevara2, Karol Estrada3
1Department of Epidemiology and Biostatistics, University of California, San Francisco.
JAMA
|July 6, 2016
まとめ
高いボディマス指数 (BMI) の遺伝的傾向は,より最近の出生コホートでより強い関連性があります. 肥満の流行のような 環境要因がBMIに 遺伝的影響を及ぼすことを示唆しています
科学分野:
- 遺伝学
- 流行病学
- 公衆衛生
背景:
- 遺伝的変異はボディマス指数 (BMI) と関連していますが 20世紀の肥満流行に伴ってその関連が進化したのかもしれません
- 黒人と白人の間には 関連性の違いがあるかもしれません
- BMIへの遺伝的傾向に対する肥満性の環境の影響については,さらなる調査が必要である.
研究 の 目的:
- より高いBMIの遺伝的傾向が,より最近の出生コホートからの個人により強く関連しているかどうかを判断する.
- 出生コホートによって示された肥満性の環境がBMIとの遺伝的関連に与える影響を評価する.
主な方法:
- ある観察研究では,健康と退職に関する研究から米国人の8788人 (1900~1958年生まれ) を分析した.
- 体重指数 (BMI) は1992年から2014年の間に最大12回評価されました.
- BMI (GRS-BMI) のマルチロカス遺伝的リスクスコアは,29の単一ヌクレオチドポリモルフィズムに基づいて計算された.
主要な成果:
- GRS-BMIは白人の参加者 (0. 99%) と黒人の参加者 (1. 37%) の BMIと有意に関連していました.
- GRS-BMIとBMIの間の関連性は,両方の人種グループにおけるより最近の出生コホートにおいてより強く見られた.
- 例えば,1943年以降に生まれた白人の参加者の間で,より高いGRS-BMIは,1924年以前に生まれた人の0.17と比較して,BMI単位差1.37と関連していました.
結論:
- BMIとBMIの遺伝的リスクスコアの関連性は,後期出生コホート (1900年−1958年) で増加した.
- これらの発見は,肥満性の環境がBMIに対する既知の遺伝的変異の影響を変化させる可能性があることを示唆している.
- 遺伝子と環境の相互作用を理解することは 肥満の治療に不可欠です
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