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Updated: Mar 18, 2026

Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy
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複数のメカニズムは,神経芽細胞腫におけるlet-7マイクロRNAファミリーを破壊する

John T Powers1, Kaloyan M Tsanov1, Daniel S Pearson1

  • 1Division of Pediatric Hematology/Oncology, Boston Children's Hospital, Boston, Massachusetts 02115, USA.

Nature
|July 8, 2016
PubMed
まとめ

高いMYCNRNAレベルは,腫瘍を抑制するlet-7マイクロRNAをスポンジ化するので,LIN28Bは神経芽細胞腫では不要である. 様々なメカニズムによって ニューロブラストーマの発生と 悪い予後を促します

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