ヒトの代謝を調節する食事と微生物の相互作用
Justin L Sonnenburg1, Fredrik Bäckhed2,3
1Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305, USA.
Nature
|July 8, 2016
まとめ
ダイエットは肥満と2型糖尿病に大きな影響を与えます 新興の研究は腸内微生物群を強調している
科学分野:
- 微生物学
- 代謝 健康
- 栄養学
背景:
- 肥満と2型糖尿病は 食事習慣と密接に関連しています
- 代謝健康における腸内微生物群の役割は 研究の分野として成長しています
- 腸内微生物群が 食事に関連した病気に及ぼす影響を理解することは 極めて重要です
研究 の 目的:
- 腸内微生物群と肥満を 結びつけるメカニズムを探るためです
- ダイエットと宿主の代謝の仲介者としての腸内微生物群の役割を明らかにする.
- 原因関係を調査し 治療的介入の可能性を調査する
主な方法:
- トランスレーション動物モデルを用いて
- ヒト集団での研究
- ダイエット,腸内微生物,代謝状態の相互作用を分析する.
主要な成果:
- 腸内微生物群が宿主の代謝に 食事による影響を及ぼすという証拠があります
- 腸内微生物の組成と 肥満を結びつけるメカニズムが 特定されています
- 動物とヒトの研究は 収束する証拠を提供する.
結論:
- 腸内微生物群は食事による代謝疾患において重要な役割を果たします
- ヒトにおける因果関係を確立することを目的としたさらなる研究が行われる.
- 腸内微生物群をターゲットにした パーソナライズされた栄養戦略は 治療の有望さを示しています
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