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The Contractile Ring02:15

The Contractile Ring

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Contractile rings are composed of microfilaments and are responsible for separating the daughter cells during cytokinesis. Contractile ring assembly proceeds along with other cell cycle events; however, very few mechanistic details are known about the timing and coordination of the contractile rings with the cell cycle.
A small GTPase, RhoA, controls the function and assembly of the contractile ring. RhoA belongs to the Ras superfamily of proteins. The activation of formins by RhoA promotes...
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Catenins01:23

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Catenins are characterized by multiple binding domains and dynamic structures that allow them to function as linker proteins in cell junction complexes. All catenins, except α-catenin, contain a characteristic protein sequence called the armadillo repeat and are therefore also called armadillo proteins.
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Catenins bind to cell adhesion molecules such as cadherins and link them to different cytoskeletal proteins depending on the type of cell junction. At the...
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The ciliary structures were first seen in 1647 by Antonie Leeuwenhoek while observing the protozoans. In lower organisms, these appendages are responsible for cell movement, while in higher organisms, these appendages help in the movement of the extracellular fluids within the body cavities.
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The adherens junctions that anchor cells together are multi-protein complexes that dynamically adapt to mechanical stimuli such as tensile forces and shear stress. Mechanosensory proteins in these junctions can sense such mechanical stimuli and undergo a shift in their conformation, resulting in an altered function — a process called mechanotransduction.
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スライドリングカテネン

Isurika R Fernando1, Marco Frasconi1,2, Yilei Wu1,3

  • 1Department of Chemistry, Northwestern University , 2145 Sheridan Road, Evanston, Illinois 60208, United States.

Journal of the American Chemical Society
|July 12, 2016
PubMed
まとめ
この要約は機械生成です。

研究者は,電子に富んだドナー-受容体の成分を減らすことで,スライディング互換環を持つ中性 [2]ケテナンを合成した. この減少はエネルギーバリアを大幅に低下させ,リングが自由に滑り,新しい機械的に相互接続された分子 (MIM) の道を開きます.

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科学分野:

  • 超分子化学
  • 有機合成
  • 材料科学

背景:

  • 機械的に相互接続された分子 (MIM) は,テンプレート指向の方法を使用して合成されます.
  • MIMにおける機械的結合は,様々な弱い相互作用によって安定化される.
  • ドナーと受容体の相互作用は,カタネーン構造の安定化に不可欠です.

研究 の 目的:

  • 電子に富んだ環をスライドして結合した中性 [2]ケイテナンを製造する戦略を策定する.
  • 相互接続されたリングのダイナミクスに対する酸化還元変化の影響を調査する.
  • 縮小されたカテネンの構造的および動的性質を特徴付ける.

主な方法:

  • サイクロビス (((パラクアット-p-フェニレン)) (CBPQT (((4+)) とクラウンエーテル (ヒドロキノンまたは1,5-ダイオキシナフタレン) を用いた変性ドナー受容体 [2]ケテナンの合成.
  • CBPQT ((4+) コンポーネントを中性形に4電子還元する.
  • 紫外線,EPR,NMRスペクトロスコーピーを用いた特徴付け,固体構造分析,量子力学計算.

主要な成果:

  • CBPQTの減少により,ドナーと受容体の相互作用が著しく弱まります.
  • 減少した [2] 鎖は,リングの動きに対するエネルギーバリアを大幅に減少させる.
  • 相互に絡み合った環は中性状態でも自由に滑り,完全に縮小されたカテネンでは固体構造がはっきりと観察される.

結論:

  • リングダイナミクスを制御する強力な戦略を提供します.
  • 滑り輪のニュートラルなカテネンは 前例のない運動の自由を示しています
  • スライディングリングのカタネンとロタキサンは,独特で調節可能な性質を示すと予測されています.