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Updated: Mar 17, 2026

Structure of HIV-1 Capsid Assemblies by Cryo-electron Microscopy and Iterative Helical Real-space Reconstruction
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Structure of HIV-1 Capsid Assemblies by Cryo-electron Microscopy and Iterative Helical Real-space Reconstruction

Published on: August 9, 2011

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HIV-1 カプシド-SP1 の 原子 モデル は,組み立て と 成熟 を 制御 する 構造 を 明らかに し て い ます

Florian K M Schur1, Martin Obr2, Wim J H Hagen3

  • 1Structural and Computational Biology Unit, European Molecular Biology Laboratory, Meyerhofstraße 1, 69117 Heidelberg, Germany. Molecular Medicine Partnership Unit, European Molecular Biology Laboratory-Universitätsklinikum Heidelberg, Heidelberg, Germany.

Science (New York, N.Y.)
|July 16, 2016
PubMed
まとめ

成熟阻害剤は未成熟のウイルス構造を安定させ,必須のGagポリタンパク質の分裂を防ぐことでHIV-1の感染性を阻害する. この研究は,未成熟のHIV-1の原子構造を明らかにし,MIの標的となる相互作用を詳細に示しています.

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