自閉症 の 煩わしい 感覚
Alexander H Tuttle1, Victoria B Bartsch1, Mark J Zylka1
1Department of Cell Biology and Physiology, UNC Neuroscience Center, The Carolina Institute for Developmental Disabilities, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Cell
|July 16, 2016
まとめ
タッチセンシングニューロンの欠乏は 自閉症とレット症候群のマウスモデルにおける社会的行動と不安に影響します 周辺神経系が 自閉症の主要な症状に 役割を果たす可能性を示唆しています
科学分野:
- 神経科学
- 発達生物学
- 遺伝学
背景:
- 自閉症スペクトル障害 (ASD) とレット症候群 (RTT) は複雑な神経発達障害である.
- 主な症状は 社会的交流の欠如と不安です
- 基礎となる生物学的メカニズムは完全に理解されていません.
研究 の 目的:
- 触覚センサーの神経細胞が 社会的な行動や不安に 果たす役割を調査する
- 外周神経系の機能障害と自閉症/RTTの現象型との関連性を調べる.
主な方法:
- 自閉症やレット症候群の特徴を示すように遺伝子操作されたマウスモデルを使用した.
- 社会的交流の行動と不安のような反応を評価した.
- 体感覚神経細胞の発達と機能を研究した.
主要な成果:
- 触覚センサーである体感覚神経の欠陥が 社会的相互作用の障害と有意に相関していることが示された.
- これらのモデルでは,体感覚神経機能障害と不安現象の増加との明確な関連が観察されました.
- 周回神経系内の異常な発達や機能の証拠を提供した.
結論:
- 触覚を感知する体感覚神経の欠陥は,自閉症とレット症候群の社会的および不安に関連する症状に絡んでいます.
- これらの発見は 周辺神経系が 自閉症の主要な症状の 発生源である可能性を示しています
- 神経発達障害に対する 周回神経系内の新しい治療目標を示唆している.
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