訪問毎の低密度脂質コレステロールの変動は,認知能力の低下,脳の血流の低下,白質の高強度負荷の増加と関連している

Roelof A J Smit1, Stella Trompet1, Behnam Sabayan1

  • 1From Department of Cardiology (R.A.J.S., S.T., J.W.J.), Section of Gerontology and Geriatrics, Department of Internal Medicine (R.A.J.S., S.T., B.S., A.J.M.d.C.), Department of Radiology (B.S., J.v.d.G., M.A.v.B.), Department of Clinical Epidemiology (S.l.C.), Department of Medical Statistics and Bioinformatics (S.l.C.), and Einthoven Laboratory for Experimental Vascular Medicine (J.W.J.), Leiden University Medical Center, Leiden, The Netherlands; and Interuniversity Cardiology Institute Netherlands, Utrecht, The Netherlands (J.W.J.).

Circulation
|July 21, 2016
PubMed
まとめ

低密度脂質タンパク質コレステロール (LDL-C) の高変動は,認知機能の低下と脳の健康に関連しています. この関連性は,平均的なLDL-Cレベルやスタチンの使用に関係なく,記憶,処理速度,脳イメージングマーカーに影響します.

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