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Updated: Mar 17, 2026

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複製フォークの安定性は,BRCA欠乏細胞に化学抵抗性を与える

Arnab Ray Chaudhuri1, Elsa Callen1, Xia Ding2

  • 1Laboratory of Genome Integrity, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

Nature
|July 23, 2016
PubMed
まとめ

PTIPタンパク質の喪失は,複製フォークの分解を防ぐことによって,Brca1/ 2遺伝子が欠けているがん細胞をDNA損傷から保護します. この発見はシスプラチンやPARP阻害剤のような化学療法剤に対する薬剤耐性メカニズムに関する新しい洞察を提供します.

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