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Updated: Mar 17, 2026

ACT1-CUP1 Assays Determine the Substrate-Specific Sensitivities of Spliceosomal Mutants in Budding Yeast
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ACT1-CUP1 Assays Determine the Substrate-Specific Sensitivities of Spliceosomal Mutants in Budding Yeast

Published on: June 30, 2022

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3.5 Å解像度での酵母活性化スプライソームの構造

Chuangye Yan1, Ruixue Wan1, Rui Bai1

  • 1Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.

Science (New York, N.Y.)
|July 23, 2016
PubMed
まとめ

この研究では,活性化されたスプライセソーム (バクト複合体) の原子構造が明らかにされ,U2,U5,U6の小さな核RNAがプレメッセンジャーRNAと相互作用してスプライシングを開始する方法が詳細に説明されています. これはmRNA前スプライシングメカニズムを理解するための分子フレームワークを提供します.

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