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Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology
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Cdk5の破壊は腫瘍PD- L1の発現を弱め,抗腫瘍免疫を促進する

R Dixon Dorand1, Joseph Nthale2, Jay T Myers2

  • 1Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. Division of Pediatric Hematology-Oncology, Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.

Science (New York, N.Y.)
|July 28, 2016
PubMed
まとめ

サイクリン依存キナーゼ5 (Cdk5) は,PD- L1を上調することによって,メドゥロブラストーマが免疫監視を回避することを可能にします. マウスのCdk5を阻害すると,T細胞媒介の腫瘍拒絶を引き起こし,Cdk5を強調する.

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