妊娠初期における母子のコカイン使用は,先天性泌尿器系異常の危険因子である
G F Chávez1, J Mulinare, J F Cordero
1Birth Defects and Genetic Diseases Branch, Centers for Disease Control, Atlanta, GA 30333.
JAMA
|August 11, 1989
まとめ
妊娠初期における母子のコカイン使用は,新生児の泌尿器系欠陥のリスクが高いことと関連しています. この研究では,生殖器臓器の欠陥との有意な関連性が見つかりませんでした.
科学分野:
- 産前流行病学 産前流行病学
- テラトロジー・テラトロジーとは
- 公衆衛生は公衆衛生である.
背景:
- 生まれつきの異常は,新生児にとって重大な健康上の課題をもたらします.
- 妊娠中の母親の薬物使用は,出生に不利な結果をもたらす既知の危険因子です.
- 以前の研究では,コカインの曝露と先天性欠陥の間の潜在的な関連が示唆されているが,特定の関連についてはさらなる調査が必要である.
研究 の 目的:
- 妊娠初期における母子のコカイン使用と,先天性泌尿器系異常の発生率との関連を調査する.
- 子宮内でコカインに曝露した乳児における尿路障害および生殖器の障害のリスクを定量化するために.
主な方法:
- 集団ベースのアトランタ出生欠陥症例対照研究 (1968年-1980年) のデータの分析.
- 尿路および生殖器の異常を患った生児と死産児を症例として含める.
- 生まれながらの欠陥のないランダムに選択された対照赤ちゃんとの比較.
- 妊婦のコカイン使用の定義は,受胎前の1ヶ月から妊娠の最初の3ヶ月までの報告された使用です.
主要な成果:
- 統計的に有意な関連性は,母子のコカイン使用と尿路障害のリスクの増加 (粗略オッズ比率=4.39) の間で発見されました.
- 母親のコカイン使用と生殖器臓器の欠陥 (オッズ比=2.26) の間には統計的に有意な関連性が見られなかった.
- この発見は,コカイン使用と尿路の異常との関連性を示す以前の動物および臨床研究と一致しています.
結論:
- 妊娠初期における母子のコカイン使用は,先天性尿路欠陥の重要なリスク因子です.
- この研究では,母子のコカイン使用と先天性生殖器官の欠陥との間に有意な関連性は見つかりませんでした.
- これらの発見は,先天性異常のリスクを軽減するために,産前ケアと薬物乱用予防プログラムの重要性を強調しています.
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