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Updated: Mar 17, 2026

Evaluation of LC3-II Release via Extracellular Vesicles in Relation to the Accumulation of Intracellular LC3-positive Vesicles
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UBQLN2は,プロテアソームによるオートファジー独立のタンパク質集積のクリアランスを媒介する

Roland Hjerpe1, John S Bett1, Matthew J Keuss2

  • 1Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, Davidson Building, Henry Wellcome Lab of Cell Biology, University of Glasgow, G12 8QQ Glasgow, UK; The MRC Protein Phosphorylation and Ubiquitylation Unit, The Sir James Black Centre, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland.

Cell
|August 2, 2016
PubMed
まとめ

タンパク質のクリアランスは 細胞の生存に不可欠です 新しい経路では UBQLN2 と HSP70 を使用して プロテアソーム経由でタンパク質集積物を除去し,その変異が神経変性を引き起こす.

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