妊娠と大動脈解剖または破裂のリスク:コホートクロスオーバー分析
Hooman Kamel1, Mary J Roman2, Alex Pitcher2
1From Department of Neurology (H.K.), Feil Family Brain and Mind Research Institute (H.K.), and Division of Cardiology M.J.R., R.B.D.), Weill Cornell Medicine, New York, NY; and Radcliffe Department of Medicine, Division of Cardiovascular Medicine, University of Oxford, Oxford, UK (A.P.). hok9010@med.cornell.edu.
Circulation
|August 6, 2016
まとめ
妊娠すると大動脈の解剖や破裂のリスクが大きく増加します. この研究では,1年後の妊娠と出産後のリスクが 4倍高いことが判明し 心血管疾患の重要な期間を示しています
科学分野:
- 心血管の健康
- 産婦人科
- 公衆衛生研究
背景:
- 妊娠中の大動脈解剖と破裂は 症例シリーズで記録されています
- 妊娠と大動脈合併症の関連性を確認する人口ベースのデータは限られている.
研究 の 目的:
- 妊娠と大動脈の解剖や破裂のリスクとの関連を調べる
- 妊娠および産後期におけるこれらの大動脈事件のリスクを定量化するために.
主な方法:
- コーホート・クロスオーバー試験の設計は,米国の3つの州からの大規模な医療データを使用した.
- 12歳以上の妊婦 (2005年−2013年) が対象となった.
- 産前6ヶ月から産後3ヶ月間のリスク期間で, 1年後の対照期間と比較して,大動脈解剖または破裂の複合的な結果が評価されました.
主要な成果:
- 65万件以上の妊娠が分析され,リスク期間中に36例,対照期間に9例の大動脈解剖/破裂が特定されました.
- 妊娠/ 産後における大動脈合併症の割合は百万人に5. 5であり,対照期には百万人に1. 4であった.
- 妊娠は著しくリスクが増加した (IRR 4. 0; 95% CI 2. 0- 8. 2).
結論:
- 大動脈の解剖や破裂のリスクは,妊娠中および産後期に大幅に増加します.
- この増加したリスクは,妊娠中および産後における心臓血管のモニタリングの重要性を強調しています.
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