脂質タンパク質に酸化したリンパ脂質 (a) 動脈壁の炎症と炎症性単細胞反応を誘発する

Fleur M van der Valk1, Siroon Bekkering1, Jeffrey Kroon1

  • 1From Department of Vascular Medicine (F.M.V.d.V., M.N., E.S.G.S.), Department of Molecular Cell Biology, Sanquin Research (J.K., J.D.v.B.), Experimental Vascular Biology, (J.v.d.B.), Department of Radiology (A.J.N.), and Department of Nuclear Medicine (H.J.V.), Academic Medical Center, Amsterdam, the Netherlands; Departments of Internal Medicine (S.B., L.A.B.J., M.G.N., N.P.R.) and Pharmacology-Toxicology (N.P.R.), Radboud UMC, Nijmegen, the Netherlands; Sulpizio Cardiovascular Center, Division of Cardiovascular Medicine (C.Y., S.T.) and Division of Endocrinology and Metabolism, Department of Medicine (J.L.W.), University California, San Diego, La Jolla; St. Boniface Hospital Research Centre, University of Manitoba, Winnipeg, Canada (A.R.); Department of Chemistry, Biochemistry and Pharmacology, University of Windsor, Windsor, Canada (C.S.); and Robarts Research Institute, Schulich School of Medicine, Western University, London, Canada (M.L.K.).

Circulation
|August 7, 2016
PubMed
まとめ

リポプロテイン (a) [Lp (a) ]が増加すると,動脈の炎症と単細胞の移動が増加し,心血管疾患を誘発する. 酸化フォスホリピド (OxPLs) はこれらの炎症促進効果を媒介し,新しい治療目標を提供します.

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