関連する実験動画

Updated: Mar 16, 2026

Parallel Interrogation of β-Arrestin2 Recruitment for Ligand Screening on a GPCR-Wide Scale using PRESTO-Tango Assay
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Parallel Interrogation of β-Arrestin2 Recruitment for Ligand Screening on a GPCR-Wide Scale using PRESTO-Tango Assay

Published on: March 10, 2020

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GPCR-Gタンパク質-β-アレスティン超複合体は持続Gタンパク質シグナル伝達を媒介する

Alex R B Thomsen1, Bianca Plouffe2, Thomas J Cahill3

  • 1Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.

Cell
|August 9, 2016
PubMed
まとめ

研究者らは,単一のGタンパク質結合受容体 (GPCR) が細胞内のGタンパク質とβ-アレスティンに同時に結合する新しい"メガプレックス"を発見した. この発見は,内蔵されたGPCRからの持続的なシグナル伝達を説明します.

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