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ゲノタイプ3のC型肝炎NS3/4Aプロテアゼにおける薬剤耐性の基礎となる分子およびダイナミックメカニズム

Djadé I Soumana1, Nese Kurt Yilmaz1, Akbar Ali1

  • 1Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School , Worcester, Massachusetts 01605, United States.

Journal of the American Chemical Society
|August 12, 2016
PubMed
まとめ

C型肝炎ウイルス (HCV) プロテアース阻害剤は,ゲノタイプ3に対して効果が低い. この研究は 構造的な変化だけでなく タンパク質阻害剤のダイナミクスの変化が この減少した効能を説明し 将来の薬の開発を導くことを示しています

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