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Updated: Mar 16, 2026

Method for Measuring the Activity of Deubiquitinating Enzymes in Cell Lines and Tissue Samples
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デウビキチナゼ OTULINは,炎症と自己免疫の重要なネガティブレギュレータである

Rune Busk Damgaard1, Jennifer A Walker1, Paola Marco-Casanova1

  • 1Medical Research Council Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK.

Cell
|August 16, 2016
PubMed
まとめ

デウビキチン酵素OTULINは,M1結合ユビキチン鎖を調節することによって,危険な炎症を予防する. OTULIN欠乏症は重度の自己炎症症症候群 (ORAS) を引き起こしますが,抗TNF療法では患者とマウスの治療が可能です.

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