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Updated: Mar 16, 2026

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
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A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators

Published on: February 20, 2018

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クラスAのGPCRの様々な活性化経路は,Gタンパク質結合領域の近くに収束する

A J Venkatakrishnan, Xavier Deupi, Guillaume Lebon

    Nature
    |August 16, 2016
    PubMed
    まとめ

    クラスAのGタンパク質結合受容体 (GPCRs) は,共通の活性化経路の収束を共有しています. 特定のトランスメブランヘリクスを含むこの保存されたメカニズムは,様々なリガンドがこれらの重要な薬物標的を活性化する方法を説明します.

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