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子供と青少年における脂質障害のスクリーニング:米国予防サービスタスクフォースの勧告声明
, Kirsten Bibbins-Domingo1, David C Grossman2
1University of California, San Francisco.
JAMA
|August 18, 2016
まとめ
20歳未満の個体における脂質障害のスクリーニングの利益と害を決定するには,現在の証拠は不十分である. スクリーニングの有効性と長期的な心血管健康結果を評価するには,さらなる研究が必要です.
科学分野:
- 心血管の健康
- 小児の健康
- 予防 医療
背景:
- コレステロールとトリグリセリドの値が上昇すると,成人では心血管疾患のリスクが増加します.
- 子供と青年の脂質障害は,将来の心血管疾患を予測する可能性があります.
- 以前のリピッドスクリーニングの勧告は2007年に制定された.
研究 の 目的:
- 子供,青少年,若年成人における脂質障害のスクリーニングに関する最新の勧告を提供すること.
- 20歳未満の個体におけるヘテロジゴト性家族性高コレステロール血症および多因子性脂質不全症のスクリーニングに関する証拠を評価する.
主な方法:
- 小児集団における脂質障害スクリーニングに関する証拠の体系的なレビュー.
- 特定のタイプの脱脂症 (家族性高コレステロール血症,多因子) のスクリーニングに焦点を当てたレビュー.
- 診断結果,治療効果,スクリーニングの害の評価
主要な成果:
- 普遍的スクリーニングと選択的スクリーニングの比較診断結果に関する証拠は限られている.
- 幼児期に開始された治療の長期的な効果と害に関するデータは少ない.
- 中間結果と成人における心血管健康の改善との関連は十分に確立されていません.
結論:
- 米国予防サービスタスクフォース (USPSTF) は,20歳未満の個体における脂質障害のスクリーニングの利益と害のバランスを評価するのに十分な証拠が見つかりませんでした.
- USPSTFは証拠不足を理由に グレードIの勧告を出した.
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