キラルの金属有機構造における分子の調整
Seungkyu Lee1, Eugene A Kapustin1, Omar M Yaghi2
1Department of Chemistry, University of California, Berkeley, CA 94720, USA. Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA. Kavli Energy NanoSciences Institute, Berkeley, CA 94720, USA. Berkeley Global Science Institute, Berkeley, CA 94720, USA.
Science (New York, N.Y.)
|August 20, 2016
まとめ
MOF-520のようなキラル金属有機フレームワークは 構造をX線微分法で決定するために 分子を正確に並べます この方法は,ギベレリンのような複雑な分子でも,絶対的な構成を明確に割り当てます.
科学分野:
- クリスタルグラフィー
- 材料科学
- 有機化学
背景:
- 有機分子の正確な3D構造と 絶対的な構成を決定することは 化学と薬物の発見において極めて重要です
- 伝統的な方法では 複雑な分子や小さな分子には 順番の良い結晶が必要です
- チラルのフレームワークは,制御された分子配列とエナチオセレクティブ結晶化の可能性を提供します.
研究 の 目的:
- 多様な有機分子構造の決定のためのキラル金属有機フレームワーク (MOF-520) の使用を調査する.
- MOF-520のキラル環境を活用して 絶対的な分子構成を明確にする
- 自然産物やエナチオマーを含む複雑な分子を結晶化および特徴づけするフレームワークの能力を実証する.
主な方法:
- MOF-520をホスト材料として利用し,ゲスト分子を協調的に結合し,並べます.
- 単一結晶X線微分法を用いて,並べられたゲスト分子構造を決定した.
- MOFの固有のキラリティを絶対的な構成割り当ての基準として適用した.
主要な成果:
- アルコール,フェノール,ダイオール,カルボキシル酸を含む16の異なる分子の正確な構造を決定しました.
- 複合植物ホルモン (ギベレリン) の構造を解明し,単一結合と二重結合を区別した.
- ラセミックジャスモニック酸のエナチオセレクティブ結晶化を達成し,その絶対的構成を直接決定した.
結論:
- MOF-520のようなキラルMOFは,X線微分法による構造決定を容易にする強力なプラットフォームを提供します.
- この方法は,従来の技術の限界を克服し,絶対的な構成を明確に割り当てることができます.
- フレームワークの有用性は,複雑な天然製品と,ラセミック混合物の直接のエナチオ選択的分解に拡張されます.
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