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関連する概念動画

Prochirality02:05

Prochirality

5.3K
The concept of prochirality leads to the nomenclature of the individual faces of a molecule and plays a crucial role in the enantioselective reaction. It is a concept where two or more achiral molecules react to produce chiral products. A typical process is the reaction of an achiral ketone to generate a chiral alcohol. Here, the achiral reactant reacts with an achiral reducing agent, sodium borohydride, to generate an equimolar mixture of the chiral enantiomers of the product. For example, an...
5.3K
SN2 Reaction: Stereochemistry02:23

SN2 Reaction: Stereochemistry

12.4K
In an SN2 reaction, the nucleophilic attack on the substrate and departure of the leaving group occurs simultaneously through a transition state. As the nucleophile approaches the substrate from the back-side, the configuration of the substrate carbon changes from tetrahedral to trigonal bipyramidal and then back to tetrahedral, leading to an inversion in the configuration of the product.
If the substrate is an achiral molecule at the α-carbon, the inversion of configuration is not...
12.4K
Chirality in Nature02:30

Chirality in Nature

17.8K
Chirality is the most intriguing yet essential facet of nature, governing life’s biochemical processes and precision. It can be observed from a snail shell pattern in a macroscopic world to an amino acid, the minutest building block of life. Most of the snails around the world have right-coiled shells because of the intrinsic chirality in their genes. All the amino acids present in the human body exist in an enantiomerically pure state, except for glycine - the sole achiral amino acid.
17.8K
Chirality02:25

Chirality

31.7K
Chirality is a term that describes the lack of mirror symmetry in an object. In other words, chiral objects cannot be superposed on their mirror images. For example, our feet are chiral, as the mirror image of the left foot, the right foot, cannot be superposed on the left foot.
Chiral objects exhibit a sense of handedness when they interact with another chiral object. For example, our left foot can only fit in the left shoe and not in the right shoe. Achiral objects — objects that have...
31.7K
Fischer Projections02:18

Fischer Projections

17.4K
Learning to draw Fischer projections of molecules and understanding their relevance plays a crucial role in the visual depiction of organic molecules. A Fischer projection is a two-dimensional projection on a planar surface to simplify the three-dimensional wedge–dash representation of molecules. This is especially helpful in the case of molecules with multiple chiral centers that can be difficult to draw. Here, all the bonds of interest are represented as horizontal or vertical lines. While...
17.4K
SN1 Reaction: Stereochemistry02:15

SN1 Reaction: Stereochemistry

10.9K
This lesson provides an in-depth discussion of the stereochemical outcomes in an SN1 reaction.
In the first step of an SN1 reaction, the bond between the electrophilic carbon and the leaving group ionizes to generate the carbocation intermediate. The second step of the mechanism is the nucleophilic attack.
In the formed carbocation, the positively charged carbon is sp2 hybridized with a trigonal planar geometry. As all the three substituents lie on the same plane, a plane of symmetry for the...
10.9K

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関連する実験動画

Updated: Mar 16, 2026

Coulomb Explosion Imaging as a Tool to Distinguish Between Stereoisomers
08:51

Coulomb Explosion Imaging as a Tool to Distinguish Between Stereoisomers

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表面反応による二次性移転

Haiming Zhang1, Zhongmiao Gong1, Kewei Sun1

  • 1Institute of Functional Nano&Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University , 199 Ren'ai Road, Suzhou, Jiangsu 215123, People's Republic of China.

Journal of the American Chemical Society
|August 23, 2016
PubMed
まとめ

表面合成を用いて,自己組み立てた分子から新しい分子にキラリティが転送された. セルフアセンブリされた前駆者の構造は,結果として得られる共性結合製品のキラリティを決定し,分子キラリティの制御を可能にしました.

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A Micropatterning Assay for Measuring Cell Chirality
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A Micropatterning Assay for Measuring Cell Chirality

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Author Spotlight: Unveiling the Potential of VSFG Microscopy in Studying Mesoscopically Heterogeneous Self-Assembled Structures
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Author Spotlight: Unveiling the Potential of VSFG Microscopy in Studying Mesoscopically Heterogeneous Self-Assembled Structures

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関連する実験動画

Last Updated: Mar 16, 2026

Coulomb Explosion Imaging as a Tool to Distinguish Between Stereoisomers
08:51

Coulomb Explosion Imaging as a Tool to Distinguish Between Stereoisomers

Published on: August 18, 2017

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Author Spotlight: Unveiling the Potential of VSFG Microscopy in Studying Mesoscopically Heterogeneous Self-Assembled Structures
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科学分野:

  • 表面化学
  • 有機合成
  • チラリティ研究

背景:

  • 分子認識と生物学的プロセスにおいて 性は非常に重要です
  • 表面合成は複雑な分子構造を作る プラットフォームを提供します
  • 合成された分子におけるキラリティの制御は大きな課題である.

研究 の 目的:

  • セルフアセンブリされた分子から共性結合された製品への二次元キラリティの移転を実現する.
  • 合成された分子のキラリティに対する前駆体自己組み立て構造の影響を調査する.
  • 表面上の合成を調査し,キラルオリゴ-p-フェニレンを作ります.

主な方法:

  • 表面合成は,Au ((111)) 基板上で行われます.
  • 1,4-ジブロモ-2,5-ディドデシルベンゼン (12DB) と1,4-ジブロモ-2,5-ディトリデシルベンゼン (13DB) を前体として使用する.
  • 構造調査のためのスキャニングトンネル顕微鏡 (STM).

主要な成果:

  • アリル-アリル結合反応は,最も近い隣接先駆体間で発生し,自己組み立てのラメラー構造が保存された.
  • 前駆体 (12DB) のホモキラルドメインはホモキラルオリゴ-p-フェニレン (OPP) ドメインを生成した.
  • 混合キラル幾何学前駆体 (13DB) は,OPPのラセミックラメラを生成した.

結論:

  • セルフアセンブリされた前駆体から共性結合された製品への二次元キラリティの移転は可能である.
  • 先駆者の自己組み立て構造は,合成された分子のキラリティを直接決定する.
  • 表面合成は,先駆体設計を通じて分子キラリティを制御する経路を提供します.