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Updated: Mar 16, 2026

Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods
07:49

Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods

Published on: July 17, 2019

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KSRの不活性状態の小分子安定化は,腫瘍性Rasシグナル伝達に対抗する

Neil S Dhawan1,2, Alex P Scopton1,2, Arvin C Dar1,2

  • 1Department of Oncological Sciences, The Tisch Cancer Institute, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.

Nature
|August 25, 2016
PubMed
まとめ

研究者は,Ras-mitogen活性化タンパク質キナーゼ (MAPK) 経路を阻害するために,Rasのキナーゼ抑制剤 (KSR) を標的とした新しい化合物を開発した. このアプローチは不活性なKSR状態を安定させ,Ras駆動がんにおける抵抗を克服するための新しい戦略を提供します.

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