TRPM2チャネルは,熱を制限し,低体温を誘導する下垂体熱センサーです
Kun Song1, Hong Wang1, Gretel B Kamm1
1Department of Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany.
Science (New York, N.Y.)
|August 27, 2016
まとめ
臨時受容体潜在メラスタチン2 (TRPM2) イオンチャネルは,体温を調節する,視床下部の温度センサーとして作用する. TRPM2は熱を抑制し,過熱を防止し,気温関連の疾患の治療目標となる可能性があります.
科学分野:
- 神経科学
- 生理学
- 分子生物学
背景:
- 体温の恒常性は 生存に不可欠で 神経系によって調節されます
- 視床下部は 体内の温度を制御する 恒温器として機能します
- 暫定受容体ポテンシャル (TRP) チャンネルは感覚知覚に関与しているが,熱調節におけるその役割は完全に理解されていない.
研究 の 目的:
- 低体内の温度センサーを 特定するためです
- 熱反応と熱調節におけるTRPM2の役割を調査する.
- 病気の治療のためにTRPM2の活性を操作する治療の可能性を探求する.
主な方法:
- TRPM2発現ニューロンを活性化および抑制するために化学遺伝学を使用した.
- 神経操作後の体温の変化を測定した.
- 低頭部ニューロンの温度センサーとしてのTRPM2の機能を調査した.
主要な成果:
- TRPM2は,下垂体ニューロンのサブ集団の温度センサーとして特定されました.
- TRPM2の活性化により,熱の反応が制限され,過熱が防止されました.
- TRPM2発現ニューロンの化学操作により 体温が変化した.
結論:
- TRPM2は気温上昇を検知し,発熱を調節する上で重要な役割を果たします.
- 視床下部のTRPM2発現ニューロンは,体温ホメオスタシスの主要な調節体です.
- TRPM2をターゲットにすると,様々な疾患状態で体温を管理するための潜在的な戦略が提供されます.
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