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Updated: Mar 15, 2026

Induction and Analysis of Epithelial to Mesenchymal Transition
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フーマレートは,表皮からメゼンキマへの移行を誘発する表皮変異剤である

Marco Sciacovelli1, Emanuel Gonçalves2, Timothy Isaac Johnson1

  • 1Medical Research Council Cancer Unit, University of Cambridge, Cambridge CB2 0XZ, UK.

Nature
|September 1, 2016
PubMed
まとめ

フマレート水素酵素の喪失はフマレートの蓄積を引き起こし,攻撃的な腎臓がんを促します. このオンコメタボライトは,表皮からメゼンキマへの移行を誘導し,表皮遺伝的調節物質を阻害し,転移と悪い結果をもたらします.

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