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Updated: Mar 15, 2026

A Macrophage Reporter Cell Assay to Examine Toll-Like Receptor-Mediated NF-kB/AP-1 Signaling on Adsorbed Protein Layers on Polymeric Surfaces
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A Macrophage Reporter Cell Assay to Examine Toll-Like Receptor-Mediated NF-kB/AP-1 Signaling on Adsorbed Protein Layers on Polymeric Surfaces

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ネクロティック・セル・センサ Clec4e は,展開されたタンパク質応答の活性化により,プロアテロゲンマクロファージ現象を促進する

Marc Clément1, Gemma Basatemur1, Leanne Masters1

  • 1From Division of Cardiovascular Medicine, University of Cambridge, Cambridge, UK (M.C., G.B., L.M., L.B., J.G., Z.M.); Institut National de la Santé et de la Recherche Médicale, Paris Cardiovascular Research Center, Paris, France (P.B., Z.M.); Iwawaki Laboratory, Advanced Scientific Research Leaders Development Unit, Gunma University, Maebashi, Gunma, Japan (T.I.); Department of Preclinical Imaging and Radiopharmacy, Werner Siemens Imaging Center and Department of Dermatology (M.K.), Eberhard Karls University, Tübingen, Germany; and Division of Molecular Immunology, Medical Institute of Bioregulation, Kyushu University, Kyushu, Japan (S.Y.).

Circulation
|September 3, 2016
PubMed
まとめ

C型レクチン受容体4e (Clec4e) の死細胞による活性化は,コレステロールの流出を阻害し,炎症を促進することによって動脈硬化を引き起こす. Clec4eシグナリングをターゲットにすることで,心臓血管疾患の新たな治療戦略が提供される可能性があります.

キーワード:
動脈硬化症細胞増殖炎症ネクロス

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