先進性非小細胞肺がんにおける新規および新興の標的治療法

Fred R Hirsch¹, Kenichi Suda², Jacinta Wiens³

¹Department of Medicine, Division of Medical Oncology and Department of Pathology, University of Colorado Cancer Center, Aurora, CO, USA; International Association for the Study of Lung Cancer, Aurora, CO, USA.

Lancet (London, England)

|September 7, 2016

まとめ

標的治療は特定の変異や免疫経路を標的として肺がん治療に革命を起こしています進行中の研究は,先進的な非小細胞肺癌の患者のアウトカムを改善するために,新しい薬の開発と耐性を克服することに焦点を当てています.

科学分野:

腫瘍学
薬理学について
分子生物学

背景:

標的治療は肺がん管理のパラダイムシフトです
現在の治療には駆動変異,細胞増殖経路,免疫チェックポイントを標的とする薬が含まれています
新しい発見や組み合わせの戦略によって研究は急速に進んでいます

研究の目的:

先進性非小細胞肺がんの標的治療における最近の進歩をレビューする.
標的治療の開発のための臨床試験データに焦点を当てること.
抵抗メカニズムの理解における進歩を強調する.

主な方法:

公開された臨床試験のレビュー
肺がんの標的治療に関するデータの分析
予測バイオマーカーと耐性メカニズムの調査

主要な成果:

肺がんの標的薬の開発に大きな進展がありました
新しい標的と組み合わせた治療法の特定
標的治療に対する耐性の理解を深めた.

結論:

標的型療法によって肺がんの治療が著しく改善されています
新しい治療法を開発し耐性を克服するには研究を継続することが重要です
臨床試験のデータは,標的型肺がん治療の進化を導く.

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