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The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
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甲状腺機能と突然の心臓死:将来的な集団ベースのコホート研究

Layal Chaker1, Marten E van den Berg1, Maartje N Niemeijer1

  • 1From Rotterdam Thyroid Center (L.C., R.P.P.), Department of Internal Medicine (L.C., B.H.C.S., R.P.P.), and Department of Epidemiology (L.C., M.E.v.d.B., M.N.N., O.H.F., A.D., A.H., M.E., B.H.C.S., R.P.P.), Erasmus University Medical Center; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA (A.H.); Departments of Medical Informatics (P.R.R.) and Cardiology (J.W.D.), Erasmus University Medical Center, Rotterdam, The Netherlands; and Inspectorate of Health Care, Utrecht, The Netherlands (B.H.C.S.).

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|September 8, 2016
PubMed
まとめ
この要約は機械生成です。

自由チロキシン (FT4) のレベルが正常範囲内であっても,急性心臓死 (SCD) のリスクの増加と関連しています. この発見は,一般集団におけるSCDの潜在的な予測因子としてFT4を強調しています.

キーワード:
死亡突然の心臓発作による死亡流行病学について甲状腺

さらに関連する動画

Methods for ECG Evaluation of Indicators of Cardiac Risk, and Susceptibility to Aconitine-induced Arrhythmias in Rats Following Status Epilepticus
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Methods for ECG Evaluation of Indicators of Cardiac Risk, and Susceptibility to Aconitine-induced Arrhythmias in Rats Following Status Epilepticus
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科学分野:

  • 内分泌学
  • 心臓病科
  • 流行病学

背景:

  • 甲状腺機能は 心血管疾患と関連しています
  • 突発性心臓死 (SCD) の危険因子として甲状腺機能を調査した以前の研究はありませんでした.

研究 の 目的:

  • 甲状腺機能と突然心臓死 (SCD) のリスクとの関連を予測した集団で評価する.

主な方法:

  • 45歳以上の10,318人の参加者を含む前向きなコホート研究 (ロッテルダム研究).
  • 甲状腺刺激ホルモンと自由タイロキシン (FT4) レベルを測定した.
  • 心血管疾患のリスク要因を調整して,SCDリスクを分析するためにコックスの比例リスクモデルと競合するリスクモデルを使用しました.

主要な成果:

  • FT4濃度が高いと,正常な甲状腺機能の範囲内でも,SCDリスクの増加 (HR 2. 28 per 1 ng/ dL FT4) が認められた.
  • FT4濃度が上昇した患者では,SCDの絶対的な10年リスクが1%から4%に増加した.
  • 感受性分析は,これらの発見の確固たるものであることを確認した.

結論:

  • FT4濃度の上昇は,突然心臓死 (SCD) のリスクの高さに関連しています.
  • この関連性は,正常な甲状腺機能を持つ個体でも持続し,FT4がSCDの独立した危険因子である可能性があることを示唆しています.