ロカス・コエルーレウスと日常記憶のドーパミン活性強化

Tomonori Takeuchi¹, Adrian J Duszkiewicz¹, Alex Sonneborn²

¹Centre for Cognitive and Neural Systems, Edinburgh Neuroscience, The University of Edinburgh, 1 George Square, Edinburgh EH8 9JZ, UK.

Nature

|September 8, 2016

まとめ

新しいものは記憶力を高めます研究者らはこのドーパミン依存的効果を介在する神経細胞は腹部タグメンタル領域ではなく記憶の強化のための新しい経路を示唆しています

科学分野:

神経科学
記憶に関する研究
神経生物学

背景:

エピソード型記憶は,人間や動物のコード化直前または直後の新しさによって強化されます.
このドーパミン依存の新鮮な効果は,以前は,腹部テグメンタル領域のチロシン・ヒドロキシラーゼ発現 (TH+) ニューロンだけに起因していた.

研究の目的:

ドーパミン依存の記憶強化を媒介する特定のニューロンを特定する.
新鮮さに関連した記憶強化におけるロカス・コエルーレウス (LC) ニューロンの役割を調査する.

主な方法:

マウスの日常的な記憶作業を活用した
ニューロンの発火感を記録した.
LC TH+ニューロンのプロジェクションと,ヒポカンプスへの腹部テグメンタル領域のTH+ニューロンのプロジェクションの比較.
LCTH+ニューロンの光遺伝的活性化が用いられている.
ベントラル・テグメンタル・エリアを無効化しました
hippocampal D1/ D5受容体阻害とアドレノ受容体阻害を投与した.

主要な成果:

ニューロンの発火は,環境の新奇性に非常に敏感です.
LC TH+ニューロンは,腹部テグメンタル領域のTH+ニューロンよりもヒポカンプスに広範囲に放出されます.
LCTH+ニューロンの光遺伝的活性化により記憶の強化が再現されました
ベントラル・テグメンタル領域の不活性化は,新奇性に関連した記憶強化に影響を与えなかった.
LC TH+の光活性化効果は,海馬のD1/D5受容体阻害によって阻害されたが,アドレノ受容体阻害によって阻害されなかった.

結論:

LOCUS coeruleusのTH+ニューロンは記憶の増強を介しています
この増強はドーパミンに依存し,海馬のD1/D5受容体を通して作用する.
LCTH+ニューロンはヒポカンプスでドーパミンを共放し,記憶を促進する.

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