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関連する概念動画

Thermosensation01:43

Thermosensation

34.6K
Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
34.6K
Body Temperature01:25

Body Temperature

5.2K
The body's temperature, measured in degrees, is determined by the balance between heat production and dissipation to the surrounding environment. For instance, if exercising vigorously, the body will produce more heat, causing sweat and dissipating that heat. Despite extreme environmental conditions and physical exertion, the human temperature-control system maintains a constant core body temperature (the temperature of deep tissues, which are the tissues located beneath the skin and other...
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Body Temperature01:07

Body Temperature

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Body temperature reflects the equilibrium between heat production and heat loss within the body. Most heat is generated by metabolically active tissues, particularly the liver, heart, brain, kidneys, and endocrine organs. At rest, skeletal muscles contribute 20–30% of total heat production, but during vigorous exercise, this can increase up to 30–40 times.
The average body temperature is approximately 37°C (98.6°F) and typically ranges from 36.1–37.2°C...
1.7K
Thermoregulation01:26

Thermoregulation

2.9K
The human body has a sophisticated thermoregulation system that employs negative feedback mechanisms to maintain an optimal core temperature. When the core temperature drops, peripheral and central thermoreceptors send signals to the hypothalamus, activating the heat-promoting center. This center triggers several responses aimed at increasing the core temperature. First, vasoconstriction reduces the flow of warm blood from internal organs to the skin so that the heat is not lost from the skin,...
2.9K
What is Homeostasis?01:16

What is Homeostasis?

66.0K
Maintaining homeostasis requires that the body continuously maintain its internal conditions. Each physiological condition has a particular set point, from body temperature to blood pressure to levels of certain nutrients. A set point is the physiological value around which the normal range fluctuates. A normal range is a restricted set of values that is optimally healthful and stable. For example, the set point for normal human body temperature is approximately 37°C (98.6°F).
66.0K
Somatosensation01:33

Somatosensation

44.6K
The somatosensory system relays sensory information from the skin, mucous membranes, limbs, and joints. Somatosensation is more familiarly known as the sense of touch. A typical somatosensory pathway includes three types of long neurons: primary, secondary, and tertiary. Primary neurons have cell bodies located near the spinal cord in groups of neurons called dorsal root ganglia. The sensory neurons of ganglia innervate designated areas of skin called dermatomes.
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関連する実験動画

Updated: Mar 15, 2026

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice
08:35

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice

Published on: March 17, 2015

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体温 を 制御 する 温感 ニューロン

Chan Lek Tan1, Elizabeth K Cooke1, David E Leib2

  • 1Department of Physiology, University of California, San Francisco, San Francisco, CA 94158, USA; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA.

Cell
|September 13, 2016
PubMed
まとめ
この要約は機械生成です。

研究 者 たち は,脳 の 中 で 体温 を 制御 する 特定の 温感 ニューロン (WSN) を 特定 し まし た. これらのニューロンは,BDNFとPACAPを共発し,熱によって活性化されると,冷却反応と冷たい行動を引き起こします.

さらに関連する動画

Recording Temperature-induced Neuronal Activity through Monitoring Calcium Changes in the Olfactory Bulb of Xenopus laevis
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Recording Temperature-induced Neuronal Activity through Monitoring Calcium Changes in the Olfactory Bulb of Xenopus laevis

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In Vivo Calcium Imaging of Neuronal Ensembles in Networks of Primary Sensory Neurons in Intact Dorsal Root Ganglia
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In Vivo Calcium Imaging of Neuronal Ensembles in Networks of Primary Sensory Neurons in Intact Dorsal Root Ganglia

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関連する実験動画

Last Updated: Mar 15, 2026

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice
08:35

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice

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Recording Temperature-induced Neuronal Activity through Monitoring Calcium Changes in the Olfactory Bulb of Xenopus laevis
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Recording Temperature-induced Neuronal Activity through Monitoring Calcium Changes in the Olfactory Bulb of Xenopus laevis

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In Vivo Calcium Imaging of Neuronal Ensembles in Networks of Primary Sensory Neurons in Intact Dorsal Root Ganglia
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In Vivo Calcium Imaging of Neuronal Ensembles in Networks of Primary Sensory Neurons in Intact Dorsal Root Ganglia

Published on: February 10, 2023

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科学分野:

  • 神経科学
  • 生理学
  • 分子生物学

背景:

  • 温度調節は 安定した体温を維持するための 重要な脳の機能です
  • 温度信号をホメオスタティック反応に変換する神経回路と特定の細胞タイプは完全に理解されていません.

研究 の 目的:

  • 熱を感知し,熱喪失反応を開始する脳の特定のニューロンを特定し,特徴づけること.
  • これらの熱感ニューロン (WSN) の分子同一性と機能的接続性を解明する.

主な方法:

  • 新しいニューロンの集団を発見するために,不偏的,活動依存のRNA配列を解析した.
  • 覚醒しているマウスで 熱刺激への反応として ニューロンの活動を監視するために 光学記録を行いました
  • 特定されたWSNの標的刺激と投影特有の操作のために使用された光遺伝学.

主要な成果:

  • 熱感性ニューロン (WSN) の集団を特定し,BDNFとPACAPの共発によって定義した.
  • 行動するマウスの環境の暖かさによって選択的にWSNが活性化することが示された.
  • WSNの光遺伝的活性化が 特定の神経経路を通じて 急速な低体温と 寒さ探しの行動を誘発することを示した.

結論:

  • BDNFとPACAPを共発するWSNは,哺乳類の体温調節における重要な細胞要素である.
  • これらのニューロンは,熱に対する自律的 (熱喪失) と行動的 (冷たい) 反応の両方を調整します.
  • 体温を調節する神経回路への 遺伝的アクセスを提供します