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Updated: Mar 15, 2026

Identification of Small Molecule-binding Proteins in a Native Cellular Environment by Live-cell Photoaffinity Labeling
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Identification of Small Molecule-binding Proteins in a Native Cellular Environment by Live-cell Photoaffinity Labeling

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エンジニアリングされたNEDD8リガスを用いた小分子タンパク質標的の直接近接タグ付け

Zachary B Hill1, Samuel B Pollock1, Min Zhuang1

  • 1Department of Pharmaceutical Chemistry and ‡Department of Cellular and Molecular Pharmacology, University of California , San Francisco, California 94158, United States.

Journal of the American Chemical Society
|September 15, 2016
PubMed
まとめ

研究者は小さな分子のタンパク質標的を 特定するための新しい近接タグ付け方法を開発しました この技術は,特定の小分子に結合するタンパク質をラベルにするために設計されたリガスを使用し,薬物発見と化学探査の開発を支援します.

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