関連する実験動画

Updated: Mar 15, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
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Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

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p53 と SET の間のアセチル化調節相互作用は,広範囲にわたる調節モードを明らかにします

Donglai Wang1, Ning Kon1, Gorka Lasso2

  • 1Institute for Cancer Genetics, Department of Pathology and Cell Biology, Herbert Irving Comprehensive Cancer Center, College of Physicians & Surgeons, Columbia University, 1130 Nicholas Ave, New York, NY 10032, USA.

Nature
|September 15, 2016
PubMed
まとめ

オンコタンパク質SETは,アセチル化されていないp53に結合し,その活性を抑制する. ストレス誘発によるp53CTDのアセチル化は,この結合を破壊し,p53を活性化し,腫瘍の回帰につながり,新しい調節メカニズムを明らかにします.

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