ウイルス性因子は,有酸素呼吸を通じてシトロバクテリアの拡大を助長する
Christopher A Lopez1, Brittany M Miller1, Fabian Rivera-Chávez1
1Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, One Shields Avenue, Davis, CA, USA.
Science (New York, N.Y.)
|September 17, 2016
まとめ
Citrobacter rodentiumの感染は結腸密室の増殖を引き起こし,酸素を増加させ,病原体の増殖を促します. この増殖を抑制すると,有酸素呼吸を制限することで,病原体の競争上の優位性が低下します.
科学分野:
- 微生物学
- 胃腸内科
- 病原体と宿主との相互作用
背景:
- Citrobacter rodentiumは,マウスの大腸密室増殖を誘発するために,タイプIIIの分泌システム (T3SS) を利用する.
- この増殖が腸内微生物群に対して 競争上の優位性を提供するメカニズムは不明である.
研究 の 目的:
- C. rodentium T3SSが誘発する結腸密閉症が体格上の優位性を与えるメカニズムを解明する.
- C. rodentiumの病原性における有酸素呼吸の役割を調査する.
主な方法:
- C. rodentium T3SSを用いたマウスの結腸縮症の誘導
- 皮質細胞増殖 (Ki67陽性細胞) と粘膜酸素化の評価
- γ- 分泌酵素阻害剤 (ディベンザゼピン) を投与して,ノッチ駆動性多発症を阻害する.
- C. rodentiumの有酸素呼吸と体調の評価
主要な成果:
- C. rodentium T3SSが誘発した増殖は,分化されていない上皮細胞の過剰な膨張を引き起こした.
- この膨張は粘膜の酸素化を増加させ,エアロビックC. rodentiumの成長を促した.
- ディベンザゼピンによる増殖抑制は,有酸素呼吸に関連した病原体の体力優位性を低下させた.
結論:
- C. rodentiumはT3SSを利用して結腸に組織病変を引き起こす.
- これらの病変は,有酸素呼吸を通じて病原体の増殖を支える腸内微生物環境を生成します.
- ハイパープラジアをターゲットにすることで,C. rodentiumの病原性を妨げる戦略となる.
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