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Updated: Mar 14, 2026

Determining Genome-wide Transcript Decay Rates in Proliferating and Quiescent Human Fibroblasts
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Determining Genome-wide Transcript Decay Rates in Proliferating and Quiescent Human Fibroblasts

Published on: January 2, 2018

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DEAD-Box Protein Dhh1pは,コドン最適性を監視することによって,mRNAの分解と翻訳をカップル化する

Aditya Radhakrishnan1, Ying-Hsin Chen2, Sophie Martin2

  • 1Program in Molecular Biophysics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.

Cell
|September 20, 2016
PubMed
まとめ

DEAD-boxタンパク質 Dhh1pはリボソームの速度を検知するセンサーとして機能し,特に分解に最適でないコドンを持つmRNAを標的にする. このメカニズムは,トランスレーションの延長率とmRNA崩壊経路を結びつける.

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Measurement of mRNA Decay Rates in Saccharomyces cerevisiae Using rpb1-1 Strains

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