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PI3Kγは免疫抑制を制御する分子スイッチです

Megan M Kaneda1, Karen S Messer1,2, Natacha Ralainirina1

  • 1Moores Cancer Center, University of California, San Diego, La Jolla, California 92093, USA.

Nature
|November 8, 2016
PubMed
まとめ

マクロファージのフォスフォノシチド3-キナーゼ・ガンマ (PI3Kγ) は,炎症とがんにおける免疫刺激と抑制の間のスイッチとして作用する. PI3Kγを阻害すると,抗腫瘍免疫が促進され,チェックポイント阻害剤による治療の有効性が向上する.

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