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Updated: Mar 14, 2026

Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics
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Published on: May 14, 2016

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薬理学的なチャペロン分子は,変異したhTERTプロモーターにおける三次DNA構造を回復することによって,がん細胞死を誘発する

Hyun-Jin Kang1, Yunxi Cui2, Holly Yin3

  • 1University of Arizona , College of Pharmacy, 1703 East Mabel Street, Tucson, Arizona 85721, United States.

Journal of the American Chemical Society
|September 20, 2016
PubMed
まとめ

ヒトテロメラーゼ逆転写酵素 (hTERT) プロモーターの癌誘発性突然変異は,G-四重体サイレンサーを破壊する. 新しい薬であるGTC365は これらの構造を再折り畳み hTERTを阻害し 癌細胞を殺すことができます

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