行動の結果を評価するための基礎状回路
Marcus Stephenson-Jones1, Kai Yu1, Sandra Ahrens1
1Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.
Nature
|November 8, 2016
まとめ
ハブンヌラ投射球体 (GPh) のニューロンは,マウスの行動結果の評価に不可欠です. これらの基礎状回路は 反対の信号を統合して 期待値を超えたり 下りたりするかどうかを判断します
科学分野:
- 神経科学
- 意思決定に関する研究
- 行動神経科学
背景:
- 意思決定,特に行動選択において 基礎帯は極めて重要です.
- 行動結果の評価における基礎状回路の正確な役割は,まだ理解されていない.
- 結果評価を理解することは 複雑な意思決定プロセスの解読の鍵です
研究 の 目的:
- 行動結果の評価におけるヘブンヌラ投射球体 (GPh) の役割を調査する.
- 結果評価において,GPh機能を調節する特定の基礎臓のインプットを特定する.
- GPhが意思決定のための情報を統合する方法を明らかにする.
主な方法:
- 結果評価を評価するために マウスでの古典的な条件付け作業
- 評価信号を模倣する GPh ニューロンの操作
- 細胞タイプ特有のシナプス操作で,入力機能を検知する.
- GPh回路の接続性をマッピングするために,狂犬病ウイルス支援のモノシナプス追跡.
主要な成果:
- 個々のマウスのGPhニューロンは 予想より良いか悪いかを二方向にコードします
- オプトジェネティックGPhの刺激/阻害は,効果的に強化/抑制された.
- 負のフィードバックとポジティブなフィードバックを評価するために,GPhに対する特定の阻害的および刺激的入力が必要でした.
- GPhは,ストライアタム (両コンパートメント) から阻害的インプットと,サブタラム核から刺激的インプットを受け取る.
結論:
- GPhは,ベースリンパ節内の行動結果を評価するために不可欠です.
- 行動の選択と結果の評価のための 異なる基礎状回路の経路情報
- GPhは相反するバレンスの情報を統合し,結果の期待の偏差をシグナルします.
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