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Updated: Feb 11, 2026

Author Spotlight: Refining Xenopus laevis Marking Techniques for Biomedical Studies
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Published on: June 28, 2024

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抗CTLA-4療法に対する抵抗のメカニズムとして,腫瘍細胞におけるIFN-γ経路遺伝子の喪失

Jianjun Gao1, Lewis Zhichang Shi1, Hao Zhao2

  • 1Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Cell
|September 27, 2016
PubMed
まとめ

インターフェロン・ガンマ (IFN-γ) 経路の遺伝子の遺伝的欠陥は,メラノーマにおける抗CTLA-4治療に対する第一耐性に関連しています. IFN-γシグナリングの喪失は,この免疫チェックポイント治療に対する不十分な反応を予測します.

キーワード:
IFN-γシグナリングメラノーマアンチCTLA-4コピー番号の変更イピリムマブ主要抵抗

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