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Cross-Modal Multivariate Pattern Analysis
Published on: November 9, 2011
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感覚経路の発達と可塑性のためのクロスモダル遺伝的枠組み
Laura Frangeul1, Gabrielle Pouchelon1, Ludovic Telley1
1Department of Basic Neurosciences, University of Geneva, 1211 Geneva, Switzerland.
Nature
|September 27, 2016
まとめ
感覚経路は同質的な遺伝プログラムを共有しています 周辺のインプットはトランスクリプションのアイデンティティと接続性を制御し,感覚システムの発達と可塑性におけるインプットに依存する遺伝的論理を明らかにします.
科学分野:
- 神経科学
- 発達生物学
- 遺伝学
背景:
- 感覚情報は 異なる皮質領域で並行して処理されます
- 各感覚様式には保存された皮質-タラモ-皮質ループが存在し,第一位および上位階のタラモ核が含まれています.
- この保存された回路のモチーフは 潜在的に共有された遺伝プログラムが 感覚の様式を超えて存在することを示唆しています
研究 の 目的:
- マウスの異なる感覚様式における第一階と高階のタラミック核の遺伝的同質性を調査する.
- 第一のタラミック核の転写的同一性と接続性を制御する周辺のインプットの役割を決定する.
- 感覚経路の設計と可塑性を裏付ける 入力に依存する遺伝的論理を明らかにする
主な方法:
- ネズミの体感覚,視覚,聴覚経路における第1次および第2次タラミック核の比較遺伝分析.
- 第1次タラミック核への周辺の入力アブレーションを含む実験操作.
- トランスクリプションプロファイリングと入力欠乏後のニューラル接続の評価.
主要な成果:
- 1次元のタラミック核は,より高い次元の核と同様に,体感覚,視覚,聴覚経路で遺伝的に同型である.
- 1次元の核における周辺のインプットアブレーションは,より高い次元の型トランスクリプションプログラムを誘導した.
- インプット欠乏は 下降皮質のインプットの再配線を 欠乏した第一階の核へと導いた.
結論:
- 保存された発達プログラムは,感覚の様式を超えて同質的なタラミック核を確立します.
- 周辺のインプットは,第1次タラミック核の転写的同一性と接続性を決定的に調節する.
- これらの発見は,保存された回路のモチーフと感覚経路の可塑性に対する入力に依存する遺伝的論理を明らかにします.
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