出生体重に関する全ゲノム関連と成人疾患との相関
Momoko Horikoshi1,2, Robin N Beaumont3, Felix R Day4
1Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Nature
|September 30, 2016
まとめ
出生体重 (BW) は成人の病気と関連しています. 初期の環境だけでなく 遺伝的要因が 重要な影響力を及ぼし 将来の心代謝の健康に 共通する遺伝的経路を明らかにします
科学分野:
- 遺伝学
- 代謝 疾患
- 発達生物学
背景:
- 2型糖尿病 (T2D) や心血管疾患などの成人代謝疾患と関連しています.
- これらの関連はしばしば 幼少期の環境要因に起因します
- 胎児と母親の要因が BW に影響する.
研究 の 目的:
- 多祖先全ゲノム関連研究 (GWAS) を用いてBWの遺伝的基礎を調査する.
- 胎児の遺伝的変異が BW にどの程度影響するかを決定する.
- BWと成人の心代謝リスク因子の遺伝的相関を調べる
主な方法:
- 15万3000人を超えるBWの多祖先GWASメタ解析を行った.
- 胎児の遺伝的変異によって説明されるBWの変異率を評価した.
- 血圧と心代謝の遺伝的相関を計算した (シストリック血圧,T2D,冠動脈疾患).
主要な成果:
- 胎児のゲノタイプが約15%のBWの変異を説明している.
- BWとシストリック血圧,T2D,冠動脈疾患との間に 重要な逆の遺伝的相関性が見つかりました
- 遺伝的要因がBWと将来の心代謝リスクの負の共変数に大きく寄与することを示した.
- 経路分析により,インスリンシグナル伝達,グルコースホメオスタシス,およびクロマチンの再構成の強化が示されました.
結論:
- 共同遺伝的影響は,早期成長 (BW) と成人の心代謝疾患との関連に寄与する.
- これらの共通遺伝効果を媒介する特定の生物学的経路を特定した.
- 胎児の遺伝子が 長期的な健康に与える影響を強調しています
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