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Updated: Jan 14, 2026

In Vivo CRISPR/Cas9 Screening to Simultaneously Evaluate Gene Function in Mouse Skin and Oral Cavity
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単一デンドリット脊髄内の自己決定性BDNF-TrkBシグナリング

Stephen C Harward1, Nathan G Hedrick1, Charles E Hall1

  • 1Neurobiology Department, Duke University Medical Center, Research Drive, Durham, North Carolina 27710, USA.

Nature
|September 30, 2016
PubMed
まとめ

この研究は,脳由来神経栄養因子 (BDNF) が刺激された樹状脊髄から迅速に放出され,その受容体TrkBを局所的に活性化することを明らかにしています. このオトクリン信号は,神経細胞における構造的および機能的長期増強 (LTP) に不可欠である.

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