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Updated: Mar 14, 2026

Dissection of Enhancer Function Using Multiplex CRISPR-based Enhancer Interference in Cell Lines
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Dissection of Enhancer Function Using Multiplex CRISPR-based Enhancer Interference in Cell Lines

Published on: June 2, 2018

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強化剤の変種は,ヒルシュプルング病における遺伝子調節ネットワークの機能障害を相乗的に誘導する

Sumantra Chatterjee1, Ashish Kapoor1, Jennifer A Akiyama2

  • 1Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Cell
|October 4, 2016
PubMed
まとめ

シス調節要素 (CREs) の一般的な配列変異は,複雑な障害を引き起こす可能性があります. この研究は,複数の変異体が RET 遺伝子発現をシネージー的に減らし,小さな効果を拡大し,病気のリスクを増やすことを示しています.

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