病院内での小児心臓発作停止時の気管管挿入と生存との関連
Lars W Andersen1, Tia T Raymond2, Robert A Berg3
1Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts2Department of Anesthesiology, Aarhus University Hospital, Aarhus, Denmark3Research Center for Emergency Medicine, Aarhus University Hospital, Aarhus, Denmark.
JAMA
|October 5, 2016
まとめ
小児性心停止時の気管管内輸は,生存率の低下と関連していました. この研究は,現在の慣行は,これらの重大な症例の早期挿管をサポートしないかもしれないことを示唆しています.
科学分野:
- 小児重症治療薬
- 心血管研究
- 蘇生科学
背景:
- トラクエの挿管は,小児の病院内心停止時に頻繁に行われます.
- 心臓発作時のインチューブ効果は不明である.
- この関連性を理解することは 蘇生プロトコルの最適化に不可欠です
研究 の 目的:
- 小児の入院中の心停止と患者の生存との関連を調査する.
- 自発的循環と神経機能の回復などの二次的なアウトカムとの関係を評価する.
主な方法:
- Get With The Guidelines-Resuscitationレジストリ (2000年〜2014年) のデータを活用した観察研究.
- 病院内での心停止を経験した小児患者 (< 18歳) が含まれており,既にある呼吸器または呼吸道支援を受けた患者を除いた.
- インチューブされた患者とインチューブされていない患者のアウトカムを比較するために,時間依存の傾向スコアマッチングを使用した.
主要な成果:
- この研究では2,294人の小児患者が分析され,そのうち68%が心停止時に気管管管注入を受けた.
- 適合したコホート (n=2270) では,インチューブによる退院までの生存率が著しく低下した (36% 対 41%, RR 0. 89; P=. 03).
- 群の間で自発的循環や好ましい神経学的結果の有意な差異は観察されなかった.
結論:
- 病院での小児心臓発作時の気管内輸液は,退院までの生存率の低下と関連していました.
- これらの発見は,この患者集団における早期の気管内管注入の現在の強調に異議を唱えます.
- 小児の蘇生中に最適な呼吸道管理戦略を明らかにするためにさらなる研究が必要である.
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