火傷に対する代謝ストレス反応:現在の理解と治療法
Craig Porter1, Ronald G Tompkins2, Celeste C Finnerty1
1Department of Surgery, University of Texas Medical Branch, Galveston, TX, USA; Shriners Hospitals for Children, Galveston, TX, USA.
Lancet (London, England)
|October 7, 2016
まとめ
重度の火傷は ストレス反応を長引かせて 代謝過剰と筋肉の衰えを 引き起こします この反応を管理し,火傷の生存者の結果を改善するために新しい戦略が必要です.
科学分野:
- 生物医学
- トラウマ研究
- メタボリック障害
背景:
- 重度の火傷は 極端で長期的な生理学的ストレス反応を引き起こします
- このストレス反応は 過剰な代謝と筋肉の衰えを伴い 怪我後の数年間も続きます
- 現在の治療法は 焼け傷の長期的な影響を 完全に軽減するには不十分です
研究 の 目的:
- 燃焼トラウマに対するストレス反応に関する 現在の知識をレビューする
- 超代謝 筋肉の衰弱 ストレスによる糖尿病
- 知識のギャップを特定し,新しい治療戦略の開発を指導する.
主な方法:
- 燃え傷の研究の最近の発展の文献レビュー.
- ストレス反応の基礎となる病理生理学的メカニズムの分析
- 将来の研究と治療介入の鍵となる分野を特定する.
主要な成果:
- 重度の火傷に対するストレス反応は,顕著な超代謝と筋肉の代謝によって特徴付けられます.
- 燃焼によるストレスは糖尿病の発生や 既存の血糖コントロールの問題を悪化させる可能性があります.
- 灼傷による慢性代謝的後遺症の理解と管理には 重要な知識の不足が残っている.
結論:
- 深刻で持続的なストレス反応は 重度の火傷の特徴です
- 熱中症や筋肉衰弱や ストレス誘発型糖尿病の治療は 焼け死者の健康状態を改善するために 極めて重要です
- 燃焼による長期的な代謝的影響を軽減するための効果的な治療戦略を開発するには,さらなる研究が不可欠です.
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