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Updated: Mar 14, 2026

Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets
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Published on: April 16, 2015

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エアロビック・グリコロシスは,表遺伝的メカニズムを通じてTヘルパー1細胞の分化を促進する

Min Peng1, Na Yin1, Sagar Chhangawala2

  • 1Immunology Program, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY 10065, USA.

Science (New York, N.Y.)
|October 7, 2016
PubMed
まとめ

乳酸脱水酵素A (LDHA) は,T細胞の代謝をサポートし,表遺伝的変化によってインターフェロン-ガンマ (IFN-γ) の生成を促進します. T細胞におけるLDHAを抑制することで,過剰なIFN-γ誘発の炎症や自己免疫疾患を防ぐことができます.

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