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Updated: Mar 14, 2026

A Reporter Assay to Analyze Intronic microRNA Maturation in Mammalian Cells
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サイクリンA2は,Mre11 mRNA翻訳を制御するRNA結合タンパク質である

Arun Kanakkanthara1, Karthik B Jeganathan1, Jazeel F Limzerwala2

  • 1Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.

Science (New York, N.Y.)
|October 7, 2016
PubMed
まとめ

サイクリンA2欠乏症はDNA修復を阻害することで染色体不安定と腫瘍を引き起こす. これは,サイクリンA2がMre11ヌクレアーストランスレーションに不可欠であり,適切な複製フォーク解像度とDNA破裂修復を保証するからです.

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