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Updated: Mar 13, 2026

Quantifying Agonist Activity at G Protein-coupled Receptors
11:45

Quantifying Agonist Activity at G Protein-coupled Receptors

Published on: December 26, 2011

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Gタンパク質構成のリガンド依存変調は,薬効性を変化させる

Sebastian George Barton Furness1, Yi-Lynn Liang1, Cameron James Nowell1

  • 1Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, 3052 VIC, Australia.

Cell
|October 11, 2016
PubMed
まとめ

カルシトニンGタンパク質結合受容体 (GPCRs) に対するリガンドの有効性は,受容体構造だけではなく,Gタンパク質構造にも依存する. この発見は バイアスアゴニズムのメカニズムに 新たな洞察をもたらします

キーワード:
BRET についてCTR についてFRET についてGタンパク質結合受容体GPCR についてTIRFカルシトニンカルシトニン受容体効能についてネイティブ PAGE

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