視覚皮質からの皮質流出は,先天的な運動行動の可塑性を促進する
Bao-Hua Liu1,2, Andrew D Huberman3, Massimo Scanziani1,2,4
1Howard Hughes Medical Institute and Center for Neural Circuits and Behavior, University of California San Diego, La Jolla, California 92093-0634, USA.
Nature
|October 13, 2016
まとめ
視覚皮質は脳幹に投影することで 光運動反射 (OKR) のような 生まれつきの運動行動に影響します これらの予測は,OKRの調整に不可欠です.
科学分野:
- 神経科学
- 視覚系
- モーター制御
背景:
- 哺乳類の視覚皮質は 皮質-フガの投影を通して脳幹と繋がり 生まれつきの運動行動に影響を与えます
- 脳幹付属光学系によって媒介される光学反射 (OKR) は網膜のイメージを安定させ,視力にとって不可欠です.
- OKRの可塑性は,前皮質と前皮質の両方の構造の潜在的な関与で,生涯の視覚的安定性を可能にします.
研究 の 目的:
- 視野皮質の脳幹への投影が,光運動反射 (OKR) の適応的可塑性を媒介する役割を調査する.
主な方法:
- 視野皮質がマウスの付属光学系に投影されるのを静止させる.
- 準視光学系に発射する特定の皮質フーガルニューロンの標的切除.
- 前立腺障害後の光運動反射 (OKR) 強化の評価
主要な成果:
- 視覚野を静止すると OKRの強化が減り この適応過程における視覚野の役割が示されます
- 付属光学系に発射する特定の皮質フーガルニューロンの切除により,OKRの強化がひどく低下した.
- OKRの強化は,視覚皮質が付属光学系に及ぼす影響の強化と関連していた.
結論:
- 視野皮質から脳幹への皮質フーガル投影は,光運動反射の適応性にとって不可欠である.
- 視覚野は 生まれつきの運動行動を 活発に調節し 感覚処理を超えて 既知の機能を拡張します
- この研究は視覚野が 生涯を通して 視覚の安定性を維持する 新しいメカニズムを明らかにしています
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