銅触媒によるシリコンプロヌクレオフィルと非活性化アルキル電極の交互結合
Weichao Xue1, Zheng-Wang Qu2, Stefan Grimme2
1Institut für Chemie, Technische Universität Berlin , Strasse des 17. Juni 115, 10623 Berlin, Germany.
Journal of the American Chemical Society
|October 18, 2016
まとめ
この研究は,アリファティック化合物から炭素-シリコン結合を形成する新しい銅触媒反応を導入します. このプロセスはアルキル基を効率的な循環と結合形成のために利用し,新しい合成経路を提供します.
科学分野:
- 有機化学
- オルガノシリコン化学
- カタリシス
背景:
- 炭素-シリコン結合の形成は有機合成において極めて重要です.
- C ((sp3) -Siのクロスカップリングのための効率的な方法の開発は,依然として課題です.
- ラジカル媒介反応は 結合構築の代替経路を提供する.
研究 の 目的:
- 銅で触媒化された新しいC ((sp3) -Siクロスカップリング反応を報告する.
- アリファティックC ((sp3) -I電ophilesとSi-B反応剤を使用する.
- アルキル基間物質とサイクル化のメカニズムを解明する.
主な方法:
- 銅で触媒化されたクロスカップリング反応.
- シリコン・ボロン反応剤をシリコン・プロヌクレオフィルとして使用する.
- 機械分析のための量子化学計算
主要な成果:
- アリファティックイオジドのC ((sp3) -Siクロスカップリングが成功しました.
- 5-エクソトリガーサイクルに携わるアルキルラジカル中間物質の観察
- Ueno-Stork型の前駆体に対する高収量と優れたダイアステレオ制御.
結論:
- C ((sp3) -Si結合形成のための新しい合成経路が確立されています.
- 反応は,分子内循環による銅触媒による基路を経由する.
- メカニズム的な洞察は計算分析によって得られ,核愛素の放出と激素のプロセスを詳細に説明しました.
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