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Updated: Mar 13, 2026

Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark
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Published on: January 26, 2018

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ALKBH1媒介のtRNA脱メチル化は翻訳を調節する

Fange Liu1, Wesley Clark2, Guanzheng Luo1

  • 1Department of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA; Howard Hughes Medical Institute, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA.

Cell
|October 18, 2016
PubMed
まとめ

哺乳類のALKBH1は,N1-メチラデノシン (m1A) 改変を除去するtRNA脱メチラーゼとして作用する. この可逆的なtRNAメチル化は,グルコースレベルに対応して,変換開始とタンパク質合成を動的に調節する.

キーワード:
ALKBH1メチラデノシン (m(1)コドン使用ダイナミック tRNA 改変tRNAデメチラーゼtRNAの脱メチル化tRNA メチル化トランスレーションの延長翻訳開始翻訳規制

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